期刊
STEM CELL RESEARCH
卷 48, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.scr.2020.101968
关键词
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资金
- Austria, Federal Ministry of Science, Research and Economy (BMWFW)
- Finland, Suomen Akatemia
- France, Agence National de la Recherche
- Germany, Bundesministerium fur Bildung und Forschung
- Portugal, Fundacao para a Ciencia e a Tecnologia
- Sweden, Vetenskapsradet
- European Union [813294]
A673T mutation in the amyloid precursor protein (APP) is a rare variant associated with a reduced risk of late-onset Alzheimer's disease (AD) and age-related cognitive decline. The A673T mutation decreases beta-amyloid (A beta) production and aggregation in neuronal cultures in vitro. Here we have identified a Finnish non-diseased male individual carrying a heterozygous A673T mutation, obtained a skin biopsy sample from him, and generated an iPSC line using commercially available integration-free Sendai virus-based kit. The established iPSC line retained the mutation, expressed pluripotency markers, had a normal karyotype, and differentiated into all three germ layers in vitro.
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