期刊
CURRENT ALZHEIMER RESEARCH
卷 13, 期 4, 页码 359-369出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1567205013666151116130104
关键词
Alzheimer's disease; astrocyte; astroglial atrophy; astrogliosis; calcium signaling; glutamate receptors; InsP(3) receptors; neuroglia; beta-amyloid
资金
- Fondazione Cariplo [2008-2319, 2014-1094]
- MiUR (PRIN
- SynAD)
- Alzheimer's Research Trust (UK)
- European Commission
- IKERBASQUE
- Ministry of Education and Science of the Russian Federation [02.B.49.21.0003]
- Lobachevsky State University of Nizhny Novgorod
- Russian Scientific Foundation [14-15-00633]
- Ministry of education of Russian Federation [RFMEFI57814X0079]
- National Institutes of Health (The Eunice Kennedy Shriver National Institute of Child Health and Human Development award) [HD078678]
- Slovenian Research Agency (ARRS) [P3 310, J3 4051, J3 3632, J36790, J3 4146]
- EduGlia ITN EU grant
- CAPES
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R21HD078678] Funding Source: NIH RePORTER
Pathological remodelling of astroglia represents an important component of the pathogenesis of Alzheimer's disease (AD). In AD astrocytes undergo both atrophy and reactivity; which may be specific for different stages of the disease evolution. Astroglial reactivity represents the generic defensive mechanism, and inhibition of astrogliotic response exacerbates b-amyloid pathology associated with AD. In animal models of AD astroglial reactivity is different in different brain regions, and the deficits of reactive response observed in entorhinal and prefrontal cortices may be linked to their vulnerability to AD progression. Reactive astrogliosis is linked to astroglial Ca2+ signalling, this latter being widely regarded as a mechanism of astroglial excitability. The AD pathology evolving in animal models as well as acute or chronic exposure to beta-amyloid induce pathological remodelling of Ca2+ signalling toolkit in astrocytes. This remodelling modifies astroglial Ca2+ signalling and may be linked to cellular mechanisms of AD pathogenesis.
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