期刊
CURRENT ALZHEIMER RESEARCH
卷 13, 期 8, 页码 912-917出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1567205013666160401115307
关键词
Alzheimer's disease; apolipoprotein E; China; genotype; polymorphism; population
资金
- National Natural Science Foundation of China (NSFC) [81161120498]
- Canadian Institutes of Health Research (CIHR) [TAD-117948]
Apolipoprotein E (ApoE) plays a vital role in cholesterol metabolism and its allele polymorphisms have been associated with several diseases including Alzheimer's disease (AD). There are few systematic studies on ApoE polymorphism and its association with AD in Chinese population. To examine this issue, participants included 4251 subjects and 404 AD patients with 390 healthy elderly residing in Chongqing city were genotyped. The results showed that the epsilon 3 allele presented the highest frequency (82%), followed by epsilon 4 (6.25%) and epsilon 2 (11.75%) in general population. epsilon 3/epsilon 3 genotype carriers are the most common ones (64.19%) and the epsilon 4/epsilon 4 had the lowest frequency (0.59%). The frequency of ApoE epsilon 4 allele frequency in AD (15.35%) was significantly higher than control (10.00%). Those carriers of two epsilon 4 allele have five time higher risk to develop AD. Our study demonstrate that ApoE epsilon 4 allele is a risk factor of AD for Chinese population.
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