期刊
CURRENT ALZHEIMER RESEARCH
卷 14, 期 4, 页码 426-440出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1567205013666160930112125
关键词
Alzheimer disease; neuropsychological; pathophysiology; anxiety; hypertension
资金
- Massachusetts Alzheimer's Disease Research Center [P50 AG005134, K23 AG033634, R01 AG027435, K24 AG035007]
- Harvard Aging Brain Study [P01 AGO36694, R01 AG037497]
The field of Alzheimer disease (AD) prevention has been a culmination of basic science, clinical, and translational research. In the past three years since the new 2011 AD diagnostic guidelines, large-scale collaborative efforts have embarked on new clinical trials with the hope of someday preventing AD. This review will shed light on the historical and scientific contexts in which these trials were based on, as well as discuss potential challenges these trials may face in the coming years. Primary preventive measures, such as lifestyle, multidomain, medication, and supplemental interventions, will be analyzed. Secondary prevention as represented by disease-modifying interventions, such as antiamyloid therapy and pioglitazone, will also be reviewed. Finally, hypotheses on future directions for AD prevention trials will be proposed.
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