期刊
SMALL
卷 16, 期 45, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202005039
关键词
chemotherapy; dimeric prodrugs; diselenide bond; redox-responsive drug release; self-assembly
类别
资金
- National Natural Science Foundation of China [81872816]
- Liaoning Revitalization Talents Program [XLYC180801]
- China Postdoctoral Innovative Talents Support Program [BX20190219]
- China Postdoctoral Science Foundation [2019M661134]
The current state of chemotherapy is far from satisfaction, restricted by the inefficient drug delivery and the off-target toxicity. Prodrug nanoassemblies are emerging as efficient platforms for chemotherapy. Herein, three docetaxel dimeric prodrugs are designed using diselenide bond, disulfide bond, or dicarbide bond as linkages. Interestingly, diselenide bond-bridged dimeric prodrug can self-assemble into stable nanoparticles with impressive high drug loading (approximate to 70%, w/w). Compared with disulfide bond and dicarbide bond, diselenide bond greatly facilitates the self-assembly of dimeric prodrug, and then improves the colloidal stability, blood circulation time, and antitumor efficacy of prodrug nanoassemblies. Furthermore, the redox-sensitive diselenide bond can specifically respond to the overexpressed reactive oxygen species and glutathione in tumor cells, leading to tumor-specific drug release. Therefore, diselenide bond bridged prodrug nanoassemblies exhibit discriminating cytotoxicity between tumor cells and normal cells, significantly alleviating the systemic toxicity of docetaxel. The present work gains in-depth insight into the impact of diselenide bond on the dimeric prodrug nanoassemblies, and provides promising strategies for the rational design of the high efficiency-low toxicity chemotherapeutical nanomedicines.
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