期刊
SMALL
卷 16, 期 39, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202002162
关键词
colloids; microgels; nano-sized drug delivery particles; polymeric micelles; protein corona; surface interactions
类别
资金
- Deutsche Forschungsgemeinschaft (DFG) [SFB 985]
- DFG [SFB 1066]
- Projekt DEAL
A recent paper demonstrated that the formation of a protein corona is not a general property of all types of nanosized objects. In fact, it varies between a massive aggregation of plasma proteins onto the nanoparticle down to traces (e.g., a few proteins per 10 nanoparticles), which can only be determined by mass spectrometry in comparison to appropriate negative controls and background subtraction. Here, differences between various types of nanosized objects are discussed in order to determine general structure-property-relations from a physico-chemical viewpoint. It is highlighted that not all nanoparticles are alike and shown that their internal morphology, especially the difference between a strongly hydrated/swollen shell versus a sharp hard surface and its accessibility, is most relevant for biomedical applications.
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