期刊
SMALL
卷 16, 期 43, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202003851
关键词
bone targeting; gold nanoclusters; NIR-II imaging; renal excretable nanoparticles
类别
资金
- National Natural Science Foundation of China [81971668, 21708032]
- Beijing Nova Program [xx2017017]
- Beijing Talents foundation
- Clinical Scientist Supporting grant of Beijing Tiantan Hospital [YSP201902]
- Radiology Department at Stanford University
- China Scholarship Council [201808510023]
Fluorescence imaging in the second near-infrared window (NIR-II, 1000-1700 nm) holds great promise for deep tissue visualization. Development of novel clinical translatable NIR-II probes is crucial for realizing the medical applications of NIR-II fluorescence imaging. Herein, the glutathione-capped gold nanoclusters (AuNCs, specifically Au-25(SG)(18)) demonstrate highly efficient binding capability to hydroxyapatite in vitro for the first time. Further in vivo NIR-II fluorescence imaging of AuNCs indicate that they accumulate in bone tissues with high contrast and signal-background ratio. AuNCs are also mainly and quickly excreted from body through renal system, showing excellent ribs and thoracic vertebra imaging because of no background signal in liver and spleen. The deep tissue penetration capability and high resolution of AuNCs in NIR-II imaging render their great potential for fluorescence-guided surgery like spinal pedicle screw implantation. Overall, AuNCs are highly promising and clinical translatable NIR-II imaging probe for visualizing bone and bone related abnormalities.
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