Stridor during sleep: description of 81 consecutive cases diagnosed in a tertiary sleep disorders-center

Study Objectives: To describe the characteristics of stridor during sleep (SDS) in a series of adults identified by video-polysomnography (V-PSG). Methods: Retrospective clinical, V-PSG, laryngoscopic, and therapeutic data of patients diagnosed with SDS in a tertiary referral sleep disorders center between 1997 and 2017. Results: A total of 81 patients were identified (56.8% males, age 61.8 +/- 11.2 years). Related etiologies were multiple system atrophy (MSA), amyotrophic lateral sclerosis, spinocerebellar ataxia type 1, anti-IgLON5 disease, fatal familial insomnia, brainstem structural lesions, vagus nerve stimulation, recurrent laryngeal nerve injury, the effect of radiotherapy on the vocal cords, cervical osteophytes, and others. Stridor during wakefulness coexisted in 13 (16%) patients and in MSA was only seen in the parkinsonian form. Laryngoscopy during wakefulness in 72 (88.9%) subjects documented vocal cord abductor impairment in 65 (90.3%) and extrinsic lesions narrowing the glottis in 2 (2.4%). The mean apnea-hypopnea index (AHI) was 21.4 +/- 18.6 and CT90 was 11.5 +/- 19.1. Obstructive AHI > 10 occurred in 52 (64.2%) patients and central apnea index >10 in 2 (2.4%). CPAP abolished SDS, obstructive apneic events and oxyhemoglobin desaturations in 58 of 60 (96.7%) titrated patients with optimal pressure of 9.0 +/- 2.3 cm H20. Tracheostomy in 19 (23.4%) and cordotomy in 3 (3.7%) subjects also eliminated SDS. Conclusions: SDS in adults is linked to conditions that damage the brainstem, recurrent laryngeal nerve, and vocal cords. V-PSG frequently detects obstructive sleep apnea and laryngoscopy usually shows vocal cord abductor dysfunction. CPAP, tracheostomy, and laryngeal surgery abolish SDS.

Automated summary

The study revealed that stridor during sleep in adults is often associated with conditions that damage the brainstem, recurrent laryngeal nerve, and vocal cords. Obstructive sleep apnea and vocal cord abductor dysfunction are commonly detected. CPAP, tracheostomy, and laryngeal surgery are effective treatments for eliminating stridor during sleep.