期刊
SEMINARS IN HEMATOLOGY
卷 57, 期 3, 页码 130-136出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.seminhematol.2020.10.001
关键词
Acute lymphoblastic leukemia; Pharmacogenomics; Precision medicine
类别
资金
- American Lebanese Syrian Associated Charities (ALSAC) [R01GM118578, P50GM115279, K08CA250418]
Inherited genetic variations may alter drug sensitivity in patients with acute lymphoblastic leukemia, predisposing to adverse treatment side effects. In this review, we discuss evidence from children and young adults with acute lymphoblastic leukemia to review the available pharmacogenomic data with an emphasis on clinically actionable and emerging discoveries, for example, genetic variants in thiopurine methyltransferase and NUDT15 that alter 6-mercaptopurine dosing. We also highlight the need for ongoing pharmacogenomic research to validate the significance of recent findings. Further research in young adults, as well as with novel therapeutics, is needed to provide optimal therapy in future trials. (C) 2020 Elsevier Inc. All rights reserved.
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