期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 109, 期 -, 页码 106-113出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2020.08.011
关键词
Necroptosis; Extracellular vesicles; MLKL; RIPK1; RIPK3; Cancer; Immunotherapy
资金
- Recanati Foundation (TAU)
- Israel Science Foundation (ISF) [1416/15, 818/18]
- Alpha-1 foundation [615533]
- U.S. - Israel Binational Science Foundation (BSF) [2017176]
- Varda and Boaz Dotal Research Center in Hemato-Oncology
Necroptosis is a form of cell death that promotes inflammation and necroptotic cells release EVs; EVs play a role in cancer and necroptotic EVs may have potential applications in cancer immunotherapy.
Necroptosis is a receptor-interacting protein kinase 3 (RIPK3)-/mixed lineage kinase domain-like(MLKL)dependent and caspase-independent form of cell death that promotes inflammation. We, and others, have recently shown that necroptotic cells release extracellular vesicles (EVs). This finding has highlighted that the impact of necroptosis extends well beyond its cell death function. In this review, we summarize the general characteristics, biogenesis, and function of EVs, as well as their role in cancer. In addition, we outline our current knowledge regarding necroptotic EVs, including their recently discovered and analyzed proteome. We examine the accumulating evidence for a role for necroptosis in anti-tumor immunity. Finally, we suggest that necroptotic EVs play an important role in the necroptosis-induced immune response and may, therefore, be exploited in cancer immunotherapy applications.
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