期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 109, 期 -, 页码 125-143出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2020.08.005
关键词
RIP kinase; Inflammation; Cell death; Bacterial infection; Viral infection; Pathogen
资金
- Monash Graduate Scholarship
- Hudson Institute of Medical Research
- Australian Government Research Training Program Scholarship
- Australian National Health and Medical Research Council Career Development Fellowship [APP1159230]
RIPKs are cellular signaling molecules crucial for inflammatory and cell death processes. This review discusses their roles in host responses to pathogens and the mechanisms by which pathogens target them for inactivation.
Receptor Interacting Protein Kinases (RIPKs) are cellular signaling molecules that are critical for homeostatic signaling in both communicable and non-communicable disease processes. In particular, RIPK1, RIPK2, RIPK3 and RIPK7 have emerged as key mediators of intracellular signal transduction including inflammation, autophagy and programmed cell death, and are thus essential for the early control of many diverse pathogenic organisms. In this review, we discuss the role of each RIPK in host responses to bacterial and viral pathogens, with a focus on studies that have used pathogen infection models rather than artificial stimulation with purified pathogen associated molecular patterns. We also discuss the intricate mechanisms of host evasion by pathogens that specifically target RIPKs for inactivation, and finally, we will touch on the controversial issue of drug development for kinase inhibitors to treat chronic inflammatory and neurological disorders, and the implications this may have on the outcome of pathogen infections.
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