Molecular cavity nanoarchitectonics for biomedical application and mechanical cavity manipulation

The design, synthesis, and functions of cavity structures have been paid much attention in supramolecular chemistry and related nanotechnology. Not limited to simple inclusion phenomena, the manipulation of cavity structures and functions are essential for stimuli-responsive functions. In addition, more advanced functions require regulation of mutual interaction, cooperative actions and harmonized actions between cavity units. With this background, a novel concept of cavity nanoarchitectonics is explained here with recent research examples. In the initial parts of this highlight, molecular cavity manipulations, mainly using modified cyclodextrins for biomedical applications, are exemplified. In these examples, molecular-level architectonics (molecular decoration) and small-scale supramolecular nanoarchitectonics are used to improve properties for pharmaceutical applications and cancer therapy. The later part of this highlight introduces future challenges in cavity nanoarchitectonics. Based on designed constructions of cavity networks and arrays, macroscopic mechanical motions can lead to cavity manipulations for drug delivery and molecular capture. From biomedical applications to mechanical cavity manipulation, the great potential and possibilities of cavity nanoarchitectonics are demonstrated in this highlight.