期刊
SCIENCE CHINA-CHEMISTRY
卷 63, 期 10, 页码 1428-1434出版社
SCIENCE PRESS
DOI: 10.1007/s11426-020-9846-4
关键词
immunogenic cell death; endoplasmic reticulum oxidative stress; aggregation-induced emission; reactive oxygen species
资金
- National Natural Science Foundation of China [51873092, 51961160730]
- National Key R&D Program of China (Intergovernmental Cooperation Project) [2017YFE0132200]
- Tianjin Science Fund for Distinguished Young Scholars [19JCJQJC61200]
- Fundamental Research Funds for the Central Universities, Nankai University
Focused oxidative stress of the specific organelles (e.g., endoplasmic reticulum (ER) and mitochondrion) of cancer cells can boost the immunogenic cell death (ICD) effect for cancer immunotherapy. Herein, an ER-targeted bioprobe with aggregation-induced emission (AIE) characteristics (TPE-PR-FFKDEL) was rationally designed and synthesized by integrating a new AIE photosensitizer with ER targeting peptide, which has been demonstrated to be able to efficiently induce ER oxidative stress to evoke ICD. Compared with the photosensitizer hypericin that is well-known as an ER-targeted ICD inducer, TPE-PR-FFKDEL can lead to more robust emission of immunostimulatory damage-associated molecular patterns such as surface-exposed cal-reticulin, ATP secretion, and high-mobility group protein B1 (HMGB1) and heat shock protein 70 (HSP 70) expression. Furthermore, a range of immune responses are activated to protect mice from the attack of cancer cellsin vivo.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据