期刊
SCIENCE
卷 370, 期 6518, 页码 856-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abd2985
关键词
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资金
- German Research Foundation [SPP2191, TRR128-2, TRR274-1, EXC2145, ID390857198, EXC 2067/1-390729940, STA 1389/5-1]
- ERC
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Academy of Finland [318434, 336490, 315950, 336471, 1308613, 1314119]
- Jane and Aatos Erkko Foundation
- EU [874735]
- Helsinki University Hospital Funds [TYH2018322]
- Swedish Research Foundation
- Marie Sklodowska-Curie Actions [799929]
- Australian Research Council's Discovery Early Career Researcher Award [DE190100565]
- Australian National Health and Medical Research Council Senior Research Fellowship [GNT1155794]
- European Regional Development Fund [2014-2020.4.01.15-0012]
- Wellcome Trust International Fellowship [WT095077MA]
- European Research Council grant GLIOGUIDE
- Estonian Research Council [PRG230, EAG79]
- University of Helsinki
- Academy of Finland (AKA) [318434, 315950, 336471, 315950, 318434] Funding Source: Academy of Finland (AKA)
- Australian Research Council [DE190100565] Funding Source: Australian Research Council
- Marie Curie Actions (MSCA) [799929] Funding Source: Marie Curie Actions (MSCA)
The causative agent of coronavirus disease 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For many viruses, tissue tropism is determined by the availability of virus receptors and entry cofactors on the surface of host cells. In this study, we found that neuropilin-1 (NRP1), known to bind furin-cleaved substrates, significantly potentiates SARS-CoV-2 infectivity, an effect blocked by a monoclonal blocking antibody against NRP1. A SARS-CoV-2 mutant with an altered furin cleavage site did not depend on NRP1 for infectivity. Pathological analysis of olfactory epithelium obtained from human COVID-19 autopsies revealed that SARS-CoV-2 infected NRP1-positive cells facing the nasal cavity. Our data provide insight into SARS-CoV-2 cell infectivity and define a potential target for antiviral intervention.
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