期刊
SCIENCE
卷 370, 期 6512, 页码 50-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abb8739
关键词
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资金
- European Research Council under the European Union [742112]
- Lundbeck foundation
- Novo Nordisk foundation
- Dr. Miriam and Sheldon Adelson Medical Research Foundation
- Foundation Leducq
- National Institute of Neurological Diseases and Stroke
- National Institute on Aging
- U.S. Army Research Office MURI program [W911NF1910280]
- Oscine Corp.
- Sana Biotechnology
- European Research Council (ERC) [742112] Funding Source: European Research Council (ERC)
Sleep is evolutionarily conserved across all species, and impaired sleep is a common trait of the diseased brain. Sleep quality decreases as we age, and disruption of the regular sleep architecture is a frequent antecedent to the onset of dementia in neurodegenerative diseases. The glymphatic system, which clears the brain of protein waste products, is mostly active during sleep. Yet the glymphatic system degrades with age, suggesting a causal relationship between sleep disturbance and symptomatic progression in the neurodegenerative dementias. The ties that bind sleep, aging, glymphatic clearance, and protein aggregation have shed new light on the pathogenesis of a broad range of neurodegenerative diseases, for which glymphatic failure may constitute a therapeutically targetable final common pathway.
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