期刊
SCIENCE
卷 370, 期 6512, 页码 61-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abb8575
关键词
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资金
- Medical Research Council (MRC)
- Alzheimer's Research UK
- Alzheimer's Society
- MRC Centre for Neuropsychiatric Genetics and Genomics [MR/L010305/1]
- Welsh Government
- Joint Programming for Neurodegeneration (JPND)
- VIB and KU Leuven (Methusalem grant)
- European Research Council (ERC) [ERC-834682]
- Fonds voor Wetenschappelijk Onderzoek
- Geneeskundige Stichting Koningin Elisabeth
- Opening the Future campaign of the Leuven Universitair Fonds
- VLAIO ICON Personalized Medicine grant [HBC.2019.2523]
- Belgian Alzheimer Research Foundation
- Alzheimer's Association USA
- MRC [MR/T04604X/1, UKDRI-3003, UKDRI-1004, MR/L023784/2] Funding Source: UKRI
To provide better prevention and treatment, we need to understand the environmental and genetic risks of Alzheimer's disease (AD). However, the definition of AD has been confounded with dementia in many studies. Thus, overinterpretation of genetic findings with regard to mechanisms and drug targets may explain, in part, controversies in the field. Here, we analyze the different forms of genetic risk of AD and how these can be used to model disease. We stress the importance of studying gene variants in the right cell types and in the right pathological context. The lack of mechanistic understanding of genetic variation has become the major bottleneck in the search for new drug targets for AD.
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