相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Unveiling invisible protein states with NMR spectroscopy
T. Reid Alderson et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2020)
Evolution of a dynamic molecular switch
Susan S. Taylor et al.
IUBMB LIFE (2019)
The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain
Sven H. Schmidt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases
Neha Amatya et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Predicting the Conformational Variability of Abl Tyrosine Kinase using Molecular Dynamics Simulations and Markov State Models
Yilin Meng et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2018)
Dynamic activation and regulation of the mitogen-activated protein kinase p38
Ganesan Senthil Kumar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases
Neel H. Shah et al.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2018)
Redefining the Protein Kinase Conformational Space with Machine Learning
Peter Man-Un Ung et al.
CELL CHEMICAL BIOLOGY (2018)
Identification and characterization of activating ABL1 1b kinase mutations: impact on sensitivity to ATP-competitive and allosteric ABL1 inhibitors
B. J. Lee et al.
LEUKEMIA (2017)
Automatic methyl assignment in large proteins by the MAGIC algorithm
Yoan R. Monneau et al.
JOURNAL OF BIOMOLECULAR NMR (2017)
Probing conformational dynamics in biomolecules via chemical exchange saturation transfer: a primer
Pramodh Vallurupalli et al.
JOURNAL OF BIOMOLECULAR NMR (2017)
The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1
Andrew A. Wylie et al.
NATURE (2017)
A water-mediated allosteric network governs activation of Aurora kinase A
Soreen Cyphers et al.
NATURE CHEMICAL BIOLOGY (2017)
Atomic view of the energy landscape in the allosteric regulation of Abl kinase
Tamjeed Saleh- et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
Local destabilization, rigid body, and fuzzy docking facilitate the phosphorylation of the transcription factor Ets-1 by the mitogen-activated protein kinase ERK2
Andrea Piserchio et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Atomic view of the energy landscape in the allosteric regulation of Abl kinase
Tamjeed Saleh- et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases
Huaibin Chen et al.
ELIFE (2017)
A dynamic hydrophobic core orchestrates allostery in protein kinases
Jonggul Kim et al.
SCIENCE ADVANCES (2017)
Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy
James A. H. Gilburt et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity
Frank E. Kwarcinski et al.
ACS CHEMICAL BIOLOGY (2016)
Exploiting E-coli auxotrophs for leucine, valine, and threonine specific methyl labeling of large proteins for NMR applications
Yoan R. Monneau et al.
JOURNAL OF BIOMOLECULAR NMR (2016)
15N and 13C- SOFAST-HMQC editing enhances 3D-NOESY sensitivity in highly deuterated, selectively [1H,13C]-labeled proteins
Paolo Rossi et al.
JOURNAL OF BIOMOLECULAR NMR (2016)
NMR Characterization of Information Flow and Allosteric Communities in the MAP Kinase p38γ
Phillip C. Aoto et al.
SCIENTIFIC REPORTS (2016)
The kinome 'at large' in cancer
Emmy D. G. Fleuren et al.
NATURE REVIEWS CANCER (2016)
Dynamics of Protein Kinases: Insights from Nuclear Magnetic Resonance
Yao Xiao et al.
ACCOUNTS OF CHEMICAL RESEARCH (2015)
Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity
Sonja Lorenz et al.
BIOCHEMICAL JOURNAL (2015)
The Ys and wherefores of protein kinase autoinhibition
Richard Bayliss et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2015)
13CHD2-CEST NMR spectroscopy provides an avenue for studies of conformational exchange in high molecular weight proteins
Enrico Rennella et al.
JOURNAL OF BIOMOLECULAR NMR (2015)
Combined automated NOE assignment and structure calculation with CYANA
Peter Guentert et al.
JOURNAL OF BIOMOLECULAR NMR (2015)
Computational Study of the DFG-Flip Conformational Transition in c-Abl and c-Src Tyrosine Kinases
Yilin Meng et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2015)
Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation
Tea Pemovska et al.
NATURE (2015)
The ins and outs of selective kinase inhibitor development
Susanne Mueller et al.
NATURE CHEMICAL BIOLOGY (2015)
Using ancient protein kinases to unravel a modern cancer drug's mechanism
C. Wilson et al.
SCIENCE (2015)
Dynamics-Driven Allostery in Protein Kinases
Alexandr P. Kornev et al.
TRENDS IN BIOCHEMICAL SCIENCES (2015)
Targeting Conformational Plasticity of Protein Kinases
Michael Tong et al.
ACS CHEMICAL BIOLOGY (2015)
NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy
Woonghee Lee et al.
BIOINFORMATICS (2015)
Kinase Regulation by Hydrophobic Spine Assembly in Cancer
Jiancheng Hu et al.
MOLECULAR AND CELLULAR BIOLOGY (2015)
Allosteric enhancement of MAP kinase p38α's activity and substrate selectivity by docking interactions
Yuji Tokunaga et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
Phosphorylation releases constraints to domain motion in ERK2
Yao Xiao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Sequence Determinants of a Specific Inactive Protein Kinase Conformation
Sanjay B. Hari et al.
CHEMISTRY & BIOLOGY (2013)
Structure and Dynamic Regulation of Abl Kinases
Shoghag Panjarian et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Allosteric inhibition through suppression of transient conformational states
Shiou-Ru Tzeng et al.
NATURE CHEMICAL BIOLOGY (2013)
NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors
Lukasz Skora et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Explaining why Gleevec is a specific and potent inhibitor of Abl kinase
Yen-Lin Lin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Deciphering the Structural Basis of Eukaryotic Protein Kinase Regulation
Hiruy S. Meharena et al.
PLOS BIOLOGY (2013)
Role of ABL family kinases in cancer: from leukaemia to solid tumours
Emileigh K. Greuber et al.
NATURE REVIEWS CANCER (2013)
Studying Invisible Excited Protein States in Slow Exchange with a Major State Conformation
Pramodh Vallurupalli et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII
Wojciech Jankowski et al.
NATURE CHEMICAL BIOLOGY (2012)
Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain
Nicholas M. Levinson et al.
PLOS ONE (2012)
Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples
Oliver F. Lange et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036
Wayne W. Chan et al.
CANCER CELL (2011)
Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis
Florian Grebien et al.
CELL (2011)
Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance
Tianjun Zhou et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2011)
Structural Instability Tuning as a Regulatory Mechanism in Protein-Protein Interactions
Li Chen et al.
MOLECULAR CELL (2011)
Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms
Natalia Jura et al.
MOLECULAR CELL (2011)
Solution structure of a minor and transiently formed state of a T4 lysozyme mutant
Guillaume Bouvignies et al.
NATURE (2011)
Comprehensive analysis of kinase inhibitor selectivity
Mindy I. Davis et al.
NATURE BIOTECHNOLOGY (2011)
Protein kinases: evolution of dynamic regulatory proteins
Susan S. Taylor et al.
TRENDS IN BIOCHEMICAL SCIENCES (2011)
BCR-ABL SH3-SH2 domain mutations in chronic myeloid leukemia patients on imatinib
Daniel W. Sherbenou et al.
BLOOD (2010)
Cell Signaling by Receptor Tyrosine Kinases
Mark A. Lemmon et al.
CELL (2010)
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors
Jianming Zhang et al.
NATURE (2010)
Kinase mutations in human disease: interpreting genotype-phenotype relationships
Piya Lahiry et al.
NATURE REVIEWS GENETICS (2010)
ABL Tyrosine Kinases: Evolution of Function, Regulation, and Specificity
John Colicelli
SCIENCE SIGNALING (2010)
Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations
Markus A. Seeliger et al.
CANCER RESEARCH (2009)
A conserved protonation-dependent switch controls drug binding in the Abl kinase
Yibing Shan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Conformational disturbance in Abl kinase upon mutation and deregulation
Roxana E. Iacob et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Targeting cancer with small molecule kinase inhibitors
Jianming Zhang et al.
NATURE REVIEWS CANCER (2009)
Structural coupling of SH2-kinase domains links fes and Abl substrate recognition and kinase activation
Panagis Filippakopoulos et al.
CELL (2008)
Solution conformations and dynamics of ABL kinase-inhibitor complexes determined by NMR substantiate the different binding modes of imatinib/nilotinib and dasatinib
Navratna Vajpai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Activation of tyrosine kinases by mutation of the gatekeeper threonine
Mohammad Azam et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
A helix scaffold for the assembly of active protein kinases
Alexandr P. Kornev et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Mutagenesis of p38α MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state
Marina Bukhtiyarova et al.
BIOCHEMISTRY (2007)
Patterns of somatic mutation in human cancer genomes
Christopher Greenman et al.
NATURE (2007)
Version 1.2 of the Crystallography and NMR system
Axel T. Brunger
NATURE PROTOCOLS (2007)
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
Brian J. Druker et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases
Silke Wiesner et al.
EMBO JOURNAL (2006)
The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants
John S. Tokarski et al.
CANCER RESEARCH (2006)
A Src-like inactive conformation in the Abl tyrosine kinase domain
Nicholas M. Levinson et al.
PLOS BIOLOGY (2006)
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase
B Nagar et al.
MOLECULAR CELL (2006)
Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the aurora kinase inhibitor VX-680
MA Young et al.
CANCER RESEARCH (2006)
Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR
DW Bell et al.
NATURE GENETICS (2005)
Did protein kinase regulatory mechanisms evolve through elaboration of a simple structural component?
N Kannan et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
E Weisberg et al.
CANCER CELL (2005)
Regulation of protein kinases: Controlling activity through activation segment conformation
B Nolen et al.
MOLECULAR CELL (2004)
Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
S Branford et al.
BLOOD (2003)
Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL
M Azam et al.
CELL (2003)
Structural basis for the autoinhibition of c-Abl tyrosine kinase
B Nagar et al.
CELL (2003)
Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop
S Roumiantsev et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
NP Shah et al.
CANCER CELL (2002)
The conformational plasticity of protein kinases
M Huse et al.
CELL (2002)
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
ME Gorre et al.
SCIENCE (2001)
Kinetic and catalytic mechanisms of protein kinases
JA Adams
CHEMICAL REVIEWS (2001)
c-Ab1 has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines
BB Brasher et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
A chemical switch for inhibitor-sensitive alleles of any protein kinase
AC Bishop et al.
NATURE (2000)
分享论文
