期刊
SCIENCE
卷 369, 期 6504, 页码 642-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaz2532
关键词
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资金
- MRC [1621658, MC_CF12266]
- Vetenskapsradet [621-2013-4685]
- HFSP [LT001027/2019]
- Wellcome Trust
- BBSRC [BB/K009001/1, RG53842]
- Cancer Research UK [FC001999, C33246/A20147]
- Francis Crick Institute
- UK Medical Research Council [FC001999]
- Biotechnology and Biological Sciences Research Council [BB/M009513/1]
- European Research Council [802960]
- Engineering and Physical Sciences Research Council [EP/R011818/1]
- Division of Biomedical and Life Sciences (Lancaster University)
- Wellcome Trust [FC001999, 203276/Z/16/Z]
- Isaac Newton Trust Research Grant (Trinity College)
- Isaac Newton Trust Research Grant (Department of Biochemistry, Cambridge)
- European Research Council (ERC) [802960] Funding Source: European Research Council (ERC)
- BBSRC [BB/P001440/1] Funding Source: UKRI
- MRC [MC_EX_G0800785, MC_UP_1201/27, MR/K015826/1] Funding Source: UKRI
Sulfolobus acidocaldarius is the closest experimentally tractable archaeal relative of eukaryotes and, despite lacking obvious cyclin-dependent kinase and cyclin homologs, has an ordered eukaryote-like cell cycle with distinct phases of DNA replication and division. Here, in exploring the mechanism of cell division in S. acidocaldarius, we identify a role for the archaeal proteasome in regulating the transition from the end of one cell cycle to the beginning of the next. Further, we identify the archaeal ESCRT-III homolog, CdvB, as a key target of the proteasome and show that its degradation triggers division by allowing constriction of the CdvB1:CdvB2 ESCRT-III division ring. These findings offer a minimal mechanism for ESCRT-III-mediated membrane remodeling and point to a conserved role for the proteasome in eukaryotic and archaeal cell cycle control.
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