期刊
REVIEWS IN MEDICAL VIROLOGY
卷 31, 期 2, 页码 -出版社
WILEY
DOI: 10.1002/rmv.2162
关键词
COVID-19; MERS-CoV; SARS-CoV; SARS-CoV-2; seasonal coronaviruses
类别
资金
- Health Research Board [HRB-CICER-2016-1871]
- Health Research Board (HRB) [HRB-CICER-2016-1871] Funding Source: Health Research Board (HRB)
Evidence on the immune response and reinfection rate following SARS-CoV-2 infection was systematically searched and summarized. Most patients seroconverted for SARS-CoV-2-specific IgG within 2 weeks. Studies on SARS-CoV suggest sustained SARS-CoV-specific IgG for 1-2 years post-infection.
In this review, we systematically searched and summarized the evidence on the immune response and reinfection rate following SARS-CoV-2 infection. We also retrieved studies on SARS-CoV and MERS-CoV to assess the long-term duration of antibody responses. A protocol based on Cochrane rapid review methodology was adhered to and databases were searched from 1/1/2000 until 26/5/2020. Of 4744 citations retrieved, 102 studies met our inclusion criteria. Seventy-four studies were retrieved on SARS-CoV-2. While the rate and timing of IgM and IgG seroconversion were inconsistent across studies, most seroconverted for IgG within 2 weeks and 100% (N = 62) within 4 weeks. IgG was still detected at the end of follow-up (49-65 days) in all patients (N = 24). Neutralizing antibodies were detected in 92%-100% of patients (up to 53 days). It is not clear if reinfection with SARS-CoV-2 is possible, with studies more suggestive of intermittent detection of residual RNA. Twenty-five studies were retrieved on SARS-CoV. In general, SARS-CoV-specific IgG was maintained for 1-2 years post-infection and declined thereafter, although one study detected IgG up to 12 years post-infection. Neutralizing antibodies were detected up to 17 years in another study. Three studies on MERS-CoV reported that IgG may be detected up to 2 years. In conclusion, limited early data suggest that most patients seroconvert for SARS-CoV-2-specific IgG within 2 weeks. While the long-term duration of antibody responses is unknown, evidence from SARS-CoV studies suggest SARS-CoV-specific IgG is sustained for 1-2 years and declines thereafter.
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