期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 281, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.resp.2020.103506
关键词
FG-4592(Roxadustat); ALI; HIF-1 alpha; Inflammation; Sepsis
资金
- national natural science foundation of China [81530064, 81801913]
Acute lung injury (ALI) is one of the most severe outcomes of sepsis which still waiting for effective treatment method. Roxadustat (FG-4592) which is often used for treatment of anemia in patients with chronic kidney disease (CKD), its affection on LPS-induced ALI haven't been evaluated. MH-S and MLE-12 cell injury and ALI mouse model was induced LPS. Several assays were used to explore the role of FG-4592 in reducing the damage caused by LPS. FG-4592 treatment significantly upregulated HIF-1 alpha and HO-1 and strikingly attenuated inflammation in vivo and in vitro. Furthermore, septic mice overexpressing HIF-1 alpha had high level of survival rate and lower expression of inflammatory factors while down-regulation can enhance the damage of LPS. HIF-1 alpha has a protective effect on acute lung injury in LPS induced septic mice. FG-4592 treatment remarkably ameliorated the LPS-induced lung injury through the stabilization of HIF-la. Besides the role in treating CKD anemia, the clinical use of FG-4592 also might be extended to ALI.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据