期刊
RESEARCH IN VETERINARY SCIENCE
卷 132, 期 -, 页码 81-87出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2020.06.002
关键词
Antimicrobial peptides; Avian beta-defensins, AvBDs; Immune-modulation; MAPK signaling pathways
资金
- National Research Foundation of the Republic of Korea [NRF-2018R1D1A1A09084049]
- Chung-Ang University Excellent Student Scholarship in 2019, Republic of Korea
- NIFA from the USDA [2017-6701526793]
Antimicrobial peptides (AMPs) protect host from pathogens as first line of defense. Especially, beta-defensins shows antimicrobial activity and immune modulation effects. Avian species also have beta-defensins as avian beta-defensins (AvBDs) from AvBD1 to AvBD14. In this study, we characterized chicken AvBD5 and demonstrated its immune modulatory functions in chicken macrophage cell line (HD11). Chicken AvBD5 is composed of a signal, pro, and mature peptides containing one alpha-helix, four beta-sheet, and three disulfide bonds. Here, we also showed that chicken AvBD5 induced Th1, Th2, and Th17 cytokines in chicken macrophage cell line and stimulated MAPK signaling pathways through ERK1/2 and p38 molecules. In addition, AvBD5 stimulated MyD88 and CD40 to regulate immune systems. Taken together, chicken AvBD5 can modulate host immune systems by inducing cytokines expression and stimulating MAPK signaling pathway.
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