期刊
REACTIVE & FUNCTIONAL POLYMERS
卷 154, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.reactfunctpolym.2020.104634
关键词
Zn(II) Phthalocyanine; Photodynamic antimicrobial chemotherapy; Asymmetric membrane polymer; Singlet oxygen quantum yield
资金
- Department of Science and Innovation
- National Research Foundation (NRF) South Africa through South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology [62620]
- Rhodes University
Membrane applications are hindered by fouling. Photoactive membranes (containing photosensitizers) show photodynamic antimicrobial chemotherapy (PACT) activity which reduces biological fouling. In this work we use phthalocyanines (Pcs) as photosensitizers. The Pcs used are: 2-(4-carboxyphenoxy)-9(10), 16(17), 23(24)-iris (dimethylamino) phthalocyaninato zinc(II) (1) and the quaternized 2-(4-carboxyphenoxy)-9(10), 16(17), 23(24)-tris(trimethylamino) phthalocyanine zinc(II) methyl sulfate (2). Complex 2 showed an enhanced singlet oxygen quantum yield (Phi(Delta)) of 0.76 compared to 0.53 for 1. Complex 2 showed enhanced PACT activity against Staphylococcus aureus giving a log reduction value of 9.4, while its precursor (complex 1) gave 0.08. The complexes were then conjugated to amine-functionalized polystyrene and embedded into polystyrene to form membranes resulting in Phi(Delta) values of 0.24 and 0.27 for complexes 1 and 2 respectively in water. The latter membrane showed better PACT activity.
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