Review of the research on anti-protein fouling coatings materials

As an amphiphilic macromolecule, protein's non-specific adsorption problem restricts the application of materials in many aspects, especially in biological media. To solve this problem, anti-protein adsorption materials have been extensively studied. Herein, we present a systematic overview of the development of non-specific anti protein fouling material. Several popular anti-protein adsorption mechanisms are proposed first, then we classify the kind of materials according to the functional groups contained in the materials and analyze the advantages of various materials. Moreover, We introduced the preparation and modification methods of antifouling coating on the surface based on numerous research, and also summarized the actual biological anti-fouling design of anti protein adsorption materials in biosensors, drug delivery, medical implants and marine ships in recent years. In the end, some personal opinions on the future development of anti-protein adsorption materials are expected. The discussion demonstrated that anti-protein adsorption properties of materials are significant for their application in biological systems. The anti-protein adsorption properties of materials are crucial to the application in biological systems. The analysis of antifouling materials in this review will guide the design and application of new materials in biological media.