期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 117, 期 43, 页码 27022-27033出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1922755117
关键词
functional hyperemia; cerebral blood flow; pericytes
资金
- Fondation Leducq (Transatlantic Network of Excellence on the Pathogenesis of Small Vessel Disease of the Brain)
- European Union [666881]
- Henry M. Jackson Foundation for the Advancement ofMilitaryMedicine [HU0001-18-2-0016]
- NIH [T32-HL-007594, K01-HL-138215, F32-HL152576, R24-HL-120847, R01-NS110656, R35-HL140027]
- CHROMus (Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling)
- TotmanMedical Research Trust
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [F32HL152576] Funding Source: NIH RePORTER
The essential function of the circulatory system is to continuously and efficiently supply the O-2 and nutrients necessary to meet the metabolic demands of every cell in the body, a function in which vast capillary networks play a key role. Capillary networks serve an additional important function in the central nervous system: acting as a sensory network, they detect neuronal activity in the form of elevated extracellular K+ and initiate a retrograde, propagating, hyperpolarizing signal that dilates upstream arterioles to rapidly increase local blood flow. Yet, little is known about how blood entering this network is distributed on a branch-to-branch basis to reach specific neurons in need. Here, we demonstrate that capillary-enwrapping projections of junctional, contractile pericytes within a postarteriole transitional region differentially constrict to structurally and dynamically determine the morphology of capillary junctions and thereby regulate branch-specific blood flow. We further found that these contractile pericytes are capable of receiving propagating IC-induced hyperpolarizing signals propagating through the capillary network and dynamically channeling red blood cells toward the initiating signal. By controlling blood flow at junctions, contractile pericytes within a functionally distinct postarteriole transitional region maintain the efficiency and effectiveness of the capillary network, enabling optimal perfusion of the brain.
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