相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD
Shuangxi Li et al.
CELL REPORTS (2020)
C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo
So Yoen Choi et al.
NATURE NEUROSCIENCE (2019)
Mechanisms and functions of ribosome-associated protein quality control
Claudio A. P. Joazeiro
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
CAT tails drive degradation of stalled polypeptides on and off the ribosome
Cole S. Sitron et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)
Mechanism for recycling tRNAs on stalled ribosomes
Matthew C. J. Yip et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)
Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in C9ORF72-ALS/FTD
Rodrigo Lopez-Gonzalez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response
Peng Wang et al.
PLOS GENETICS (2019)
Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies
Amit Berson et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)
MISTERMINATE Mechanistically Links Mitochondrial Dysfunction with Proteostasis Failure
Zhihao Wu et al.
MOLECULAR CELL (2019)
Ageing as a risk factor for neurodegenerative disease
Yujun Hou et al.
NATURE REVIEWS NEUROLOGY (2019)
Amyotrophic Lateral Sclerosis-associated GGGGCC repeat expansion promotes Tau phosphorylation and toxicity
Hua He et al.
NEUROBIOLOGY OF DISEASE (2019)
Physiological, Pathological, and Targetable Membraneless Organelles in Neurons
Veronica H. Ryan et al.
TRENDS IN NEUROSCIENCES (2019)
C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A
Thomas G. Moens et al.
ACTA NEUROPATHOLOGICA (2019)
Pathways of cellular proteostasis in aging and disease
Courtney L. Klaips et al.
JOURNAL OF CELL BIOLOGY (2018)
Disease Mechanisms of C9ORF72 Repeat Expansions
Tania F. Gendron et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2018)
Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD
Thomas G. Moens et al.
ACTA NEUROPATHOLOGICA (2018)
Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis
Yong-Jie Zhang et al.
NATURE MEDICINE (2018)
Insights into C9ORF72-Related ALS/FTD from Drosophila and iPSC Models
Yeliz Yuva-Aydemir et al.
TRENDS IN NEUROSCIENCES (2018)
Vms1p is a release factor for the ribosome-associated quality control complex
Olga Zurita Rendon et al.
NATURE COMMUNICATIONS (2018)
C9orf72 Dipeptide Repeats Cause Selective Neurodegeneration and Cell-Autonomous Excitotoxicity in Drosophila Glutamatergic Neurons
Wangchao Xu et al.
JOURNAL OF NEUROSCIENCE (2018)
Release of Ubiquitinated and Non-ubiquitinated Nascent Chains from Stalled Mammalian Ribosomal Complexes by ANKZF1 and Ptrh1
Kazushige Kuroha et al.
MOLECULAR CELL (2018)
Vmsl and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes
Rati Verma et al.
NATURE (2018)
C9orf72-mediated ALS and FTD: multiple pathways to disease
Rubika Balendra et al.
NATURE REVIEWS NEUROLOGY (2018)
G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo
Roberto Simone et al.
EMBO MOLECULAR MEDICINE (2018)
Homeostatic plasticity can be induced and expressed to restore synaptic strength at neuromuscular junctions undergoing ALS-related degeneration
Sarah Perry et al.
HUMAN MOLECULAR GENETICS (2017)
Cytosolic proteostasis through importing of misfolded proteins into mitochondria
Linhao Ruan et al.
NATURE (2017)
CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides
Kamena K. Kostova et al.
SCIENCE (2017)
In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing
Beatriz A. Osuna et al.
ELIFE (2017)
Cytosolic Protein Vms1 Links Ribosome Quality Control to Mitochondrial and Cellular Homeostasis
Toshiaki Izawa et al.
CELL (2017)
Visualization of cytosolic ribosomes on the surface of mitochondria by electron cryo-tomography
Vicki A. M. Gold et al.
EMBO REPORTS (2017)
C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles
Kyung-Ha Lee et al.
CELL (2016)
Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits
Quentin Defenouillere et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
OPA1 processing in cell death and disease - the long and short of it
Thomas MacVicar et al.
JOURNAL OF CELL SCIENCE (2016)
Decoding ALS: from genes to mechanism
J. Paul Taylor et al.
NATURE (2016)
Failure of RQC machinery causes protein aggregation and proteotoxic stress
Young-Jun Choe et al.
NATURE (2016)
Ribosome-associated protein quality control
Onn Brandman et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
Poly(GR) in C9ORF72-Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons
Rodrigo Lopez-Gonzalez et al.
NEURON (2016)
Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts
Nicholas J. Kramer et al.
SCIENCE (2016)
Engineered AAA plus proteases reveal principles of proteolysis at the mitochondrial inner membrane
Hui Shi et al.
NATURE COMMUNICATIONS (2016)
Ribosome-associated protein quality control
Onn Brandman et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation
Ryo Yonashiro et al.
ELIFE (2016)
Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts
Elisa Onesto et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2016)
Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD
Steven Boeynaems et al.
SCIENTIFIC REPORTS (2016)
FTD/ALS-associated poly(GR) protein impairs the Notch pathway and is recruited by poly(GA) into cytoplasmic inclusions
Dejun Yang et al.
ACTA NEUROPATHOLOGICA (2015)
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
Ke Zhang et al.
NATURE (2015)
GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport
Brian D. Freibaum et al.
NATURE (2015)
Differential Toxicity of Nuclear RNA Foci versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS
Helene Tran et al.
NEURON (2015)
Localized translation near the mitochondrial outer membrane: An update
Chen Lesnik et al.
RNA BIOLOGY (2015)
Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains
Peter S. Shen et al.
SCIENCE (2015)
FUS Interacts with HSP60 to Promote Mitochondrial Damage
Jianwen Deng et al.
PLOS GENETICS (2015)
GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function
Alondra Schweizer Burguete et al.
eLife (2015)
Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration
Ryuta Ishimura et al.
SCIENCE (2014)
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins
Sarah Mizielinska et al.
SCIENCE (2014)
Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway
Kyu-Sun Lee et al.
GENES & DEVELOPMENT (2013)
A Cotranslational Ubiquitination Pathway for Quality Control of Misfolded Proteins
Feng Wang et al.
MOLECULAR CELL (2013)
Principles of Cotranslational Ubiquitination and Quality Control at the Ribosome
Stefanie Duttler et al.
MOLECULAR CELL (2013)
Reactivation of stalled polyribosomes in synaptic plasticity
Tyson E. Graber et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration
Zihui Xu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong et al.
SCIENCE (2013)
A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress
Onn Brandman et al.
CELL (2012)
Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death
Hakryul Jo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Production of Ribosome-Released Nascent Proteins with Optimal Physical Properties
David R. Ziehr et al.
ANALYTICAL CHEMISTRY (2010)
MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo
Hiroshi Hirai et al.
MOLECULAR CANCER THERAPEUTICS (2010)
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
Raphael Kopan et al.
CELL (2009)
A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration
Jessie Chu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Electrostatics in the Ribosomal Tunnel Modulate Chain Elongation Rates
Jianli Lu et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused inactivation of Drosophila Pink1 is rescued by by Parkin
Yufeng Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
Ira E. Clark et al.
NATURE (2006)
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
Jeehye Park et al.
NATURE (2006)
The valosin-containing protein (VCP) is a target of Akt signaling required for cell survival
Franck Vandermoere et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins
JB Klein et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The ubiquitin proteasome system in neurodegenerative diseases: Sometimes the chicken, sometimes the egg
A Ciechanover et al.
NEURON (2003)