期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 117, 期 43, 页码 26660-26671出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2007635117
关键词
bioceramic; titanium; 3D printing; cranial reconstruction; osteoinduction
资金
- BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy
- Vastra Gotaland Region
- Swedish Research Council [2018-02891, 2017-04728]
- Swedish Foundation for Strategic Research [RMA15-0110]
- Swedish government
- county councils, the ALF (Avtal om Lakarutbildning och Forskning) agreement [ALFGBG725641]
- IngaBritt and Arne Lundberg Foundation
- Hjalmar Svensson Foundation
- Adlerbertska Foundation
- Sylvan Foundation
- Area of Advance Materials of Chalmers and University of Gothenburg Biomaterials within the Strategic Research Area initiative launched by the Swedish government
- Swedish Research Council [2017-04728] Funding Source: Swedish Research Council
The repair of large cranial defects with bone is a major clinical challenge that necessitates novel materials and engineering solutions. Three-dimensionally (3D) printed bioceramic (BioCer) implants consisting of additively manufactured titanium frames enveloped with CaP BioCer or titanium control implants with similar designs were implanted in the ovine skull and at s.c. sites and retrieved after 12 and 3 mo, respectively. Samples were collected for morphological, ultrastructural, and compositional analyses using histology, electron microscopy, and Raman spectroscopy. Here, we show that BioCer implants provide osteoinductive and microarchitectural cues that promote in situ bone regeneration at locations distant from existing host bone, whereas bone regeneration with inert titanium implants was confined to ingrowth from the defect boundaries. The BioCer implant promoted bone regeneration at nonosseous sites, and bone bonding to the implant was demonstrated at the ultrastructural level. BioCer transformed to carbonated apatite in vivo, and the regenerated bone displayed a molecular composition indistinguishable from that of native bone. Proof-of-principle that this approach may represent a shift from mere reconstruction to in situ regeneration was provided by a retrieved human specimen, showing that the BioCer was transformed into well-vascularized osteonal bone, with a morphology, ultrastructure, and composition similar to those of native human skull bone.
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