期刊
POULTRY SCIENCE
卷 100, 期 1, 页码 55-63出版社
ELSEVIER
DOI: 10.1016/j.psj.2020.09.087
关键词
nonalcoholic fatty liver disease; Paeteria scandens; cell cycle; apoptosis; network pharmacology
资金
- National Natural Science Foundation of China [31302134]
- National Natural Science Foundation of China's Guizhou [2017-1191]
- Natural Science Foundation of Sichuan Province [20GJHZ0076]
This study aimed to determine the target of Paeteria scandens in nonalcoholic fatty liver disease (NAFLD) by analyzing the effective components of the compounds, constructing a drug-compound-target-disease network, and verifying the inhibitory effect of Paeteria scandens on NAFLD through experiments. The identified candidate targets of Paeteria scandens were shown to play significant roles in cell cycle, apoptosis, and related signal pathways, suggesting it may be a promising treatment strategy for NAFLD.
The aim of the study is to determine the target of Paeteria scandens in nonalcoholic fatty liver disease (NAFLD). The Chinese herbal medicine pharmacology data and analysis platform were used to search and screen for the effective components of the Paeteria scandens compounds and to analyze the possible therapeutic targets based on network topology. In addition, various known disease target databases were enrolled, the therapeutic target proteins in NAFLD were screened, and a protein-protein interaction network was constructed. Enrichment analysis was performed on key nodes. Finally, the inhibitory effect of Paeteria scandens on NAFLD was verified by experiments. We identified 33 major candidate targets of Paeteria scandens and successfully constructed a drugcompound-target-disease network. Abovementioned targets revealed by gene enrichment analysis have played a significant role in the cell cycle, apoptosis, and related signal pathways. We demonstrated that Paeteria scandens downregulated serum triglyceride and lipopolysaccharides levels in NAFLD chickens by feeding with a high-capacity diet and endotoxin of Salmonella enteritidis was given by gavage. Paeteria scandens may regulate the hepatic cell cycle and apoptosis through the Salmonella infection pathway, Toll-like receptor signaling pathway, and apoptosis pathway. For NAFLD, Paeteria scandens may be a promising, long-lasting treatment strategy.
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