期刊
PLOS ONE
卷 15, 期 9, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0238637
关键词
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资金
- Ecological Research Institute at Vassar College
- Marist College School of Science
- NIH [1R15GM117479-01]
- NIH Office of Research Infrastructure Programs [P40 OD010440]
Neonicotinoids, a class of insecticides structurally similar to nicotine that target biting and sucking insects, are the most widely used insecticides today, in part due to their supposed low toxicity in other organisms. However, a growing body of research has found that even low doses of neonicotinoids can induce unexpected negative effects on the physiology and survival of a wide range of non-target organisms. Importantly, no work has been done on the commercial formulations of pesticides that include imidacloprid as the active ingredient, but that also contain many other components. The present study examines the sublethal effects of Tree and Shrub(TM) (T+S), a commercial insecticide containing the neonicotinoid imidacloprid as its active ingredient, onCaenorhabditis elegans. We discovered that T+S significantly stunted the overall growth in wildtype nematodes, an effect that was exacerbated by concurrent exposure to heat stress. T+S also negatively impacted fecundity as measured by increased germline apoptosis, a decrease in egg-laying, and fewer viable offspring. Lastly, exposure to T+S resulted in degenerative changes in nicotinic cholinergic neurons in wildtype nematodes. As a whole, these findings demonstrate widespread toxic effects of neonicotinoids to critical functions in nematodes.
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