期刊
PHYTOTHERAPY RESEARCH
卷 35, 期 3, 页码 1163-1175出版社
WILEY
DOI: 10.1002/ptr.6882
关键词
cardiotoxicity; doxorubicin; natural compounds; Nrf2
资金
- Mashhad University of Medical Sciences
This article reviewed natural compounds that have shown protective effects against DOX-induced cardiac injury by inducing the Nrf2 signaling pathway. Compounds such as asiatic acid and baicalein were found to effectively reduce DOX cardiotoxicity.
Cardiotoxicity is the main concern for long-term use of the doxorubicin (DOX). Reactive oxygen species (ROS) generation leads to oxidative stress that significantly contributes to the cardiac damage induced by DOX. The nuclear factor erythroid 2-related factor (Nrf2) acts as a protective player against DOX-induced myocardial oxidative stress. Several natural compounds (NCs) with anti-oxidative effects, were examined to suppress DOX cardiotoxicity such as asiatic acid, alpha-linolenic acid, apigenin, baicalein, beta-lapachone, curdione, dioscin, ferulic acid,Ganoderma lucidumpolysaccharides, genistein, ginsenoside Rg3, indole-3-carbinol, naringenin-7-O-glucoside, neferine, p-coumaric acid, pristimerin, punicalagin, quercetin, sulforaphane, and tanshinone IIA. The present article, reviews NCs that showed protective effects against DOX-induced cardiac injury through induction of Nrf2 signaling pathway.
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