Roles of plant-derived bioactive compounds and relatedmicroRNAsin cancer therapy

Plant-derived bioactive compounds, often called phytochemicals, are active substances extracted from different plants. These bioactive compounds can release therapeutic potential abilities via reducing antitumor drugs side effects or directly killing cancer cells, and others also can adjust cancer initiation and progression via regulating microRNAs (miRNAs) expression, and miRNA can regulate protein-coding expression by restraining translation or degrading target mRNA. A mass of research showed that plant-derived bioactive compounds including tanshinones, astragaloside IV, berberine, ginsenosides and matrine can inhibit tumor growth and metastasis by rescuing aberrant miRNAs expression, which has influence on tumor progression, microenvironment and drug resistance in multifarious cancers. This review aims to provide a novel understanding of plant-derived bioactive compounds targeting miRNAs and shed light on their future clinical applications.

Automated summary

Plant-derived bioactive compounds can inhibit tumor growth and metastasis by regulating miRNA expression, influencing tumor progression, microenvironment, and drug resistance in various cancers. This review aims to provide a new understanding of the targeting of miRNAs by plant-derived bioactive compounds and shed light on their potential clinical applications.