期刊
PHYTOTHERAPY RESEARCH
卷 35, 期 2, 页码 657-679出版社
WILEY
DOI: 10.1002/ptr.6854
关键词
clinical trials; essential oils; molecular pathways; nervous system; neuropharmacology
资金
- Innovation Centre (University of Plymouth)
- Made For Life Organics
Essential oils have a wide range of biological activities and can produce anxiolytic, antidepressant, sedative, and anticonvulsant effects on the nervous system. Animal models have shown involvement of multiple neurotransmitter systems leading to measurable physiological effects in the brain, and clinical trials have demonstrated their influence on physiological parameters and psychological effects. More research is needed to validate their influence on the human central nervous system and their potential as drugs for mental illnesses.
Essential oils have been used as remedies since ancient times for the treatment of numerous illnesses on account of their wide range of biological activities. Recent preclinical and clinical studies have shown varying pharmacological responses in the nervous system leading to anxiolytic, antidepressant, sedative, and anticonvulsant effects. Experimentation in animal models has evidenced the involvement of multiple neurotransmitter systems in the mode of action of essential oils, resulting in measurable physiological effects in the brain. Additionally, clinical trials have demonstrated the influence of essential oils in physiological parameters such as blood pressure, heart rate, respiratory rate, brain waves composition, and cortisol serum levels with concomitant psychological effects. Although there is growing evidence of measurable effects of essential oils in animal brains, more clinical research is required to validate their influence in the human central nervous system. This will enable the development of essential oil-based drugs for the treatment of mental illnesses such as depression, anxiety and dementia.
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