期刊
PHYTOCHEMISTRY
卷 178, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2020.112459
关键词
Aconitum anthoroideum DC.; Ranunculaceae; Diterpenoid alkaloids; Anthoroidine a; Anthoroidine B; Neuroprotective activities; Acetylcholinesterase inhibitory effects
资金
- National Natural Science Foundation of China [81773605]
- Interdisciplinary Frontier Basic Research Project of SWJTU [2682017QY04]
- Science and Technology Program of Sichuan, China [2018JY0077]
Nine unprecedented diterpenoid alkaloid, including a diterpenoid alkaloid featuring a diterpenoid moiety, anthoroidine A; one bisditerpenoid alkaloid joined with a carbon-carbon single bond, anthoroidine B; three racemulosine-type C-20-diterpenoid alkaloids, anthoroidines C-E; one hetidine-type C-20-diterpenoid alkaloid, anthoroidine F; and three hetisine-type C-20-diterpenoid alkaloids, anthoroidines G-I, together with ten known diterpenoid alkaloids were isolated from Aconitum anthoroideum DC. Their structures were established via detailed spectroscopic analyses. Most of the isolated compounds along with five known diterpenoid alkaloids obtained in a previous study were screened for neuroprotective activities and acetylcholinesterase inhibitory effects. Nominine showed potent protective activity against MPP+-induced apoptosis in SH-SY5Y cells, with a rescue rate of 34.4% (50 mu M). Rotundifosine F showed a significant inhibitory activity against AChE (IC50 = 0.3 mu M). The structure-activity relationship of these alkaloids is also briefly discussed.
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