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Oncotarget (2016)
SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability
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Sudden unexpected death in epilepsy: Identifying risk and preventing mortality
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TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation
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Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models
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NATURE COMMUNICATIONS (2014)
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MOLECULAR CELL (2013)
Prognostic impact of SUMO-specific protease 1 (SENP1) in prostate cancer patients undergoing radical prostatectomy
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RIM1α SUMOylation Is Required for Fast Synaptic Vesicle Exocytosis
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Polymorphism M55V in gene encoding small ubiquitin-like modifier 4 (SUMO4) protein associates with susceptibility to type 1 (and type 2) diabetes
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DeSUMOylating isopeptidase: a second class of SUMO protease
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EMBO REPORTS (2012)
Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions
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SUMO-specific Protease 1 Regulates Mitochondrial Biogenesis through PGC-1α
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A Novel SUMO1-specific Interacting Motif in Dipeptidyl Peptidase 9 (DPP9) That Is Important for Enzymatic Regulation
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MOLECULAR CELL (2012)
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Phosphorylation of Ubc9 by Cdk1 Enhances SUMOylation Activity
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Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition
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Crystal structure of DeSI-1, a novel deSUMOylase belonging to a putative isopeptidase superfamily
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A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis
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SCIENCE (2012)
Defective Sumoylation Pathway Directs Congenital Heart Disease
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SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans
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SUMOylation and de-SUMOylation in response to DNA damage
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FEBS LETTERS (2011)
Tripartite Motif-Containing Protein 28 Is a Small Ubiquitin-Related Modifier E3 Ligase and Negative Regulator of IFN Regulatory Factor 7
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Structural and Functional Roles of Daxx SIM Phosphorylation in SUMO Para log-Selective Binding and Apoptosis Modulation
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MOLECULAR CELL (2011)
NF-κB Induction of the SUMO Protease SENP2: A Negative Feedback Loop to Attenuate Cell Survival Response to Genotoxic Stress
Moon Hee Lee et al.
MOLECULAR CELL (2011)
A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma
Corine Bertolotto et al.
NATURE (2011)
SUMO1-dependent modulation of SERCA2a in heart failure
Changwon Kho et al.
NATURE (2011)
HPV E6 proteins target Ubc9, the SUMO conjugating enzyme
Phillip R. Heaton et al.
VIRUS RESEARCH (2011)
SUMO chains: polymeric signals
Alfred C. O. Vertegaal
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Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts
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Induction of SENP1 in Endothelial Cells Contributes to Hypoxia-driven VEGF Expression and Angiogenesis
Ying Xu et al.
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In Vivo Identification of Sumoylation Sites by a Signature Tag and Cysteine-targeted Affinity Purification
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
SENP3-mediated De-conjugation of SUMO2/3 from Promyelocytic Leukemia Is Correlated with Accelerated Cell Proliferation under Mild Oxidative Stress
Yan Han et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis
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JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Kv1.1 Potassium Channel Deficiency Reveals Brain-Driven Cardiac Dysfunction as a Candidate Mechanism for Sudden Unexplained Death in Epilepsy
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Site-Specific Identification of SUMO-2 Targets in Cells Reveals an Inverted SUMOylation Motif and a Hydrophobic Cluster SUMOylation Motif
Ivan Matic et al.
MOLECULAR CELL (2010)
Regulation of DNA Repair through DeSUMOylation and SUMOylation of Replication Protein A Complex
Hong Dou et al.
MOLECULAR CELL (2010)
Active site remodelling accompanies thioester bond formation in the SUMO E1
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NATURE (2010)
Listeria monocytogenes impairs SUMOylation for efficient infection
David Ribet et al.
NATURE (2010)
PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia
X. Kang et al.
ONCOGENE (2010)
Arsenic Trioxide Controls the Fate of the PML-RARα Oncoprotein by Directly Binding PML
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SCIENCE (2010)
The Ligase PIAS1 Restricts Natural Regulatory T Cell Differentiation by Epigenetic Repression
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SCIENCE (2010)
Neural KCNQ (Kv7) channels
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BRITISH JOURNAL OF PHARMACOLOGY (2009)
SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation
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EMBO JOURNAL (2009)
MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission
Emelie Braschi et al.
EMBO REPORTS (2009)
Analyses of multiple single-nucleotide polymorphisms in the SUMO4/IDDM5 region in affected sib-pair families with type I diabetes
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GENES AND IMMUNITY (2009)
SUMOylation and De-SUMOylation: Wrestling with Life's Processes
Edward T. H. Yeh
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
SUMOylation Attenuates the Function of PGC-1α
Miia M. Rytinki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
SUMOylation regulates Kv2.1 and modulates pancreatic β-cell excitability
Xiao-Qing Dai et al.
JOURNAL OF CELL SCIENCE (2009)
Phospho-Regulated SUMO Interaction Modules Connect the SUMO System to CK2 Signaling
Per Stehmeier et al.
MOLECULAR CELL (2009)
Structure of the Siz/PIAS SUMO E3 Ligase Siz1 and Determinants Required for SUMO Modification of PCNA
Ali A. Yunus et al.
MOLECULAR CELL (2009)
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
Yaron Galanty et al.
NATURE (2009)
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses
Ye Zheng et al.
NATURE (2009)
Principles of ubiquitin and SUMO modifications in DNA repair
Steven Bergink et al.
NATURE (2009)
A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9
Firaz Mohideen et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity
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SCIENCE (2009)
A stress-dependent SUMO4 sumoylation of its substrate proteins
Wenzhong Wei et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3
Mei-Ling Kuo et al.
CELL CYCLE (2008)
Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: Implications for diabetic ventricular dysfunction after myocardial infarction
Tetsuro Shishido et al.
CIRCULATION RESEARCH (2008)
Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases
Chawon Yun et al.
JOURNAL OF CELL BIOLOGY (2008)
Loss of SUMO1 in mice affects RanGAP1 localization and formation of PML nuclear bodies, but is not lethal as it can be compensated by SUMO2 or SUMO3
Evgenij Evdokimov et al.
JOURNAL OF CELL SCIENCE (2008)
Sumo-1 function is dispensable in normal mouse development
Fu-Ping Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Ubc9 sumoylation regulates SUMO target discrimination
Puck Knipscheer et al.
MOLECULAR CELL (2008)
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation
Michael H. Tatham et al.
NATURE CELL BIOLOGY (2008)
Arsenic degrades PML or PML - RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway
Valerie Lallemand-Breitenbach et al.
NATURE CELL BIOLOGY (2008)
Targeting the PIAS1 SUMO ligase pathway to control inflammation
Bin Liu et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2008)
TH 17 cells in development:: an updated view of their molecular identity and genetic programming
Chen Dong
NATURE REVIEWS IMMUNOLOGY (2008)
Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells
Tasneem Bawa-Khalfe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The E3 ligase Topors induces the accumulation of polysumoylated forms of DNA topoisomerase I in vitro and in vivo
Eva Hammer et al.
FEBS LETTERS (2007)
SUMO-Specific protease 1 is essential for stabilization of HIF1α during hypoxia
Jinke Cheng et al.
CELL (2007)
RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1α during hypoxia
Alberto Carbia-Nagashima et al.
CELL (2007)
SUMO-targeted ubiquitin ligases in genome stability
John Prudden et al.
EMBO JOURNAL (2007)
Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins
Huaiyu Sun et al.
EMBO JOURNAL (2007)
Control of specificity and magnitude of NF-κB and STAT1-mediated gene activation through PIASy and PIAS1 cooperation
Samuel Tahk et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Structure and analysis of a complex between SUMO and Ubc9 illustrates features of a conserved E2-Ubl interaction
Allan D. Capili et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation
Puck Knipscheer et al.
EMBO JOURNAL (2007)
Modification in reverse: the SUMO proteases
Debaditya Mukhopadhyay et al.
TRENDS IN BIOCHEMICAL SCIENCES (2007)
Proinflammatory stimuli induce IKKα-mediated phosphorylation of PIAS1 to restrict inflammation and immunity
Bin Liu et al.
CELL (2007)
Targeting SUMO E1 to ubiquitin ligases - A viral strategy to counteract sumoylation
Roberto Boggio et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The SUMO protease SENP5 is required to maintain mitochondrial morphology and function
Rodolfo Zunino et al.
JOURNAL OF CELL SCIENCE (2007)
SUMO protease SENP1 induces isomerization of the scissile peptide bond
Linnan Shen et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)
Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors
Ding-Yen Lin et al.
MOLECULAR CELL (2006)
An extended consensus motif enhances the specificity of substrate modification by SUMO
Shen-Hsi Yang et al.
EMBO JOURNAL (2006)
The regulation of INK4/ARF in cancer and aging
William Y. Kim et al.
CELL (2006)
SUSP1 antagonizes formation of highly SUMO2/3-conjugated species
Debaditya Mukhopadhyay et al.
JOURNAL OF CELL BIOLOGY (2006)
SUMO1 haploinsufficiency leads to cleft lip and palate
Fowzan S. Alkuraya et al.
SCIENCE (2006)
Role of desumoylation in the development of prostate cancer
Jinke Cheng et al.
NEOPLASIA (2006)
The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing
Lin Nan Shen et al.
BIOCHEMICAL JOURNAL (2006)
Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2
Yoko Itahana et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Interactions between PIAS proteins and SOX9 result in an increase in the cellular concentrations of SOX9
Takako Hattori et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes
G Bossis et al.
MOLECULAR CELL (2006)
PDSM, a motif for phosphorylation-dependent SUMO modification
V Hietakangas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif - A reversal of the bound orientation
J Song et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice
K Nacerddine et al.
DEVELOPMENTAL CELL (2005)
A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation
D Owerbach et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1
YH Kim et al.
FEBS LETTERS (2005)
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ
G Pascual et al.
NATURE (2005)
Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo
S Weger et al.
FEBS LETTERS (2005)
Human MMS21/NSE2 is a SUMO ligase required for DNA repair
PR Potts et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Disruption of the murine PIASx gene results in reduced testis weight
H Santti et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2005)
SUMO-1 promotes association of SNURF (RNF4) with PML nuclear bodies
M Häkli et al.
EXPERIMENTAL CELL RESEARCH (2005)
Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1
LM Lois et al.
EMBO JOURNAL (2005)
Sumoylation of MITF and its related family members TFE3 and TFEB
AJ Miller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection
MH Tatham et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Sumol conjugates and participates in mitochondrial substrates mitochondrial fission
Z Harder et al.
CURRENT BIOLOGY (2004)
Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1
D Bailey et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
R Rajendra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes
DH Guo et al.
NATURE GENETICS (2004)
A mechanism for inhibiting the SUMO pathway
R Boggio et al.
MOLECULAR CELL (2004)
SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1
JK Cheng et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
PIASy-deficient mice display modest defects in IFN and Wnt signaling
W Roth et al.
JOURNAL OF IMMUNOLOGY (2004)
The transactivating function of peroxisome proliferator-activated receptor γ is negatively regulated by SUMO conjugation in the amino-terminal domain
D Yamashita et al.
GENES TO CELLS (2004)
Protein inhibitor of activated STAT y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life
KA Wong et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Control of peroxisome proliferator-activated receptor γ2 stability and activity by SUMOylation
ZE Floyd et al.
OBESITY RESEARCH (2004)
Identification of a SUMO-binding motif that recognizes SUMO-modified proteins
J Song et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns
JM Craig et al.
HUMAN MOLECULAR GENETICS (2003)
Role of an N-terminal site of Ubc9 in SUMO-1,-2, and-3 binding and conjugation
MH Tatham et al.
BIOCHEMISTRY (2003)
The polycomb protein Pc2 is a SUMO E3
MH Kagey et al.
CELL (2003)
Tumor suppression by Ink4a-Arf:: progress and puzzles
SW Lowe et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2003)
KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum
NA Singh et al.
BRAIN (2003)
Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes
Y Miyauchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Targeted insertion results in a rhombomere 2-specific Hoxa2 knockdown and ectopic activation of Hoxa1 expression
SY Ren et al.
DEVELOPMENTAL DYNAMICS (2002)
PIAS3 induces SUMO-1 modification and transcriptional repression of IRF-1
K Nakagawa et al.
FEBS LETTERS (2002)
Transcription factor Sp3 is silenced through SUMO modification by PIAS1
A Sapetschnig et al.
EMBO JOURNAL (2002)
Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex
H Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase
O Kirsh et al.
EMBO JOURNAL (2002)
Association of the human SUMO-1 protease SENP2 with the nuclear pore
J Hang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction
MH Glickman et al.
PHYSIOLOGICAL REVIEWS (2002)
The nucleoporin RanBP2 has SUMO1 E3 ligase activity
A Pichler et al.
CELL (2002)
An E3-like factor that promotes SUMO conjugation to the yeast septins
ES Johnson et al.
CELL (2001)
Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9
MH Tatham et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Involvement of PIAS1 in the sumoylation of tumor suppressor p53
T Kahyo et al.
MOLECULAR CELL (2001)
The small ubiquitin-like modifier-1 (SUMO-1) consensus sequence mediates Ubc9 binding and is essential for SURIO-1 modification
DA Sampson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
HIFα targeted for VHL-mediated destruction by proline hydroxylation:: Implications for O2 sensing
M Ivan et al.
SCIENCE (2001)
Covalent modification of p73α by SUMO-1 -: Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif
A Minty et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Ubiquitin-like proteins: new wines in new bottles
ETH Yeh et al.
GENE (2000)
Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast
E Mossessova et al.
MOLECULAR CELL (2000)
Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9
WD Xu et al.
EXPERIMENTAL CELL RESEARCH (2000)
Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3
H Saitoh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Differential regulation of sentrinized proteins by a novel sentrin-specific protease
LM Gong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
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