期刊
PHARMACOLOGICAL RESEARCH
卷 159, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2020.104924
关键词
Hypoxia-inducible factor-1 alpha; Diabetic retinopathy; Neovascularization; Vascular endothelial growth factor; Inhibitor
资金
- Natural Foundation of Heilongjiang Province [China] [H2015057]
- Postgraduate Research & Practice Innovation Program of Harbin Medical University [China] [YJSSJCX2019-15HYD]
Diabetic retinopathy (DR) is a serious condition that can cause blindness in diabetic patients. It is a neurovascular disease, but the pathogenesis leading to the onset of this disease is still not completely understood. However, hypoxia with subsequent neovascularization is a characteristic phenomenon observed with DR. Cellular response to hypoxia is mediated by the transcriptional regulator hypoxia-inducible factor (HIF). Long-term research has shown that one isotype of HIF, HIF-1 alpha, may play a pivotal role under hypoxic conditions, and an increasing number of studies have shown that HIF-1 alpha and its target genes contribute to retinal neovascularization. Therefore, targeting HIF-1 alpha may lead to more effective DR treatments. This review describes the possible mechanisms of HIF-1 alpha in neovascularization of DR. Furthermore, various inhibitors of HIF-1 alpha that may have viable potential in the treatment of DR are also discussed.
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