期刊
PHARMACOLOGICAL RESEARCH
卷 159, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2020.104997
关键词
Remyelination; Neuroinflammation; Microglia; Flavonoids; Agathisflavone; Estrogen receptors
资金
- Multiple Sclerosis Society [40]
- Biological Sciences Research Council [BB/M029379/1]
- Coordination of Personnel Improvement of Higher Level (CAPES) [88881.117666/2016-01]
- Coordination of Personnel Improvement of Higher Level (PDSE Scholarship) [88881.133939/2016-01]
- Foundation for Research Support of the State of Bahia [INT 0016/2016]
- National Council for Scientific and Technological Development (CNPq) [140333/2016-9]
- BBSRC [BB/M029379/1] Funding Source: UKRI
Myelin loss is the hallmark of the demyelinating disease multiple sclerosis (MS) and plays a significant role in multiple neurodegenerative diseases. A common factor in all neuropathologies is the central role of microglia, the intrinsic immune cells of the central nervous system (CNS). Microglia are activated in pathology and can have both pro- and anti-inflammatory functions. Here, we examined the effects of the flavonoid agathisflavone on microglia and remyelination in the cerebellar slice model following lysolecithin induced demyelination. Notably, agathisflavone enhances remyelination and alters microglial activation state, as determined by their morphology and cytokine profile. Furthermore, these effects of agathisflavone on remyelination and microglial activation were inhibited by blockade of estrogen receptor a. Thus, our results identify agathisflavone as a novel compound that may act via ER to regulate microglial activation and enhance remyelination and repair.
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