Evidence for maternal diet-mediated effects on the offspring microbiome and immunity: implications for public health initiatives

Diets rich in saturated fats have become a staple globally. Fifty percent of women of childbearing age in the United States are obese or overweight, with diet being a significant contributor. There is increasing evidence of the impact of maternal high-fat diet on the offspring microbiome. Alterations of the neonatal microbiome have been shown to be associated with multiple morbidities, including the development of necrotizing enterocolitis, atopy, asthma, metabolic dysfunction, and hypertension among others. This review provides an overview of the recent studies and mechanisms being examined on how maternal diet can alter the immune response and microbiome in offspring and the implications for directed public health initiatives for women of childbearing age. Impact Maternal diet is important in shaping the offspring microbiome and neonatal immune system. Reviews the current literature in the field and suggests potential mechanisms and areas of research to be targeted. Highlights the current scope of our knowledge of ideal nutrition during pregnancy and consideration for enhanced public health initiatives to promote well-being of the future generation.

Automated summary

Maternal diet plays a crucial role in shaping the offspring microbiome and neonatal immune system. This review discusses recent studies and mechanisms related to how maternal diet can impact the immune response and microbiome of offspring, highlighting the importance of targeted public health initiatives for women of childbearing age. It also emphasizes the current understanding of optimal nutrition during pregnancy and the need for enhanced public health efforts to promote the well-being of future generations.