期刊
PEDIATRIC INFECTIOUS DISEASE JOURNAL
卷 40, 期 3, 页码 186-190出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0000000000002950
关键词
encephalitis; encephalopathy; cerebral edema; children
Limited data on childhood encephalitis in Latin America prompted a study in Costa Rica to examine clinical presentation, etiology, and outcomes in pediatric patients. The study revealed diverse etiologies, with enterovirus and Streptococcus pneumoniae being common culprits and a significant morbidity and mortality rate associated with acute encephalitis. Early and aggressive treatment with antivirals, antibiotics, and anticerebral edema measures was found to be crucial for improving outcomes in children with acute encephalitis.
Background: Limited data are available on childhood encephalitis in Latin America. Our study aimed to increase insight on clinical presentation, etiology and outcome of children with acute encephalitis in Costa Rica. Methods: We conducted a prospective, observational study during an 8-month period at the Hospital Nacional de Ninos Dr. Carlos Saenz Herrera in Costa Rica. Case definition was according to International Encephalitis Consortium in children <13 years. We analyzed demographic characteristics, clinical symptoms, neurologic imaging, etiology, treatment and mortality. Results: Forty patients were identified. Mean age was 5 years and 57.5% were male. Most frequently neurologic symptoms were altered mental status (100.0%), headache (57.5%) and seizures (52.5%). Etiology was determined in 52.5% of cases. Probable or confirmed viral etiology was identified in 6 cases (15.0%) and bacterial etiology in also 6 cases (15.0%). A possible etiology was identified in 7 cases (17.5%). Autoimmune encephalitis was diagnosed in 2 patients (5.0%). Enterovirus and Streptococcus pneumoniae were the most common confirmed agents. No cases of herpes simplex virus were found. Etiology of 19 cases (47.5%) remained unknown. Sequelae were reported in 45.0% of patients. Mortality rate was 15.0% (6 cases), 3 caused by virus (adenovirus, human herpesvirus 6, enterovirus), 2 by bacteria (S. pneumoniae, Haemophilus influenzae type b) and 1 of unknown etiology. Diffuse cerebral edema was the most important mortality predictor (P < 0.001). Conclusions: Acute encephalitis in our study was associated with significant morbidity and mortality. Early and aggressive antiviral, antibiotic and anticerebral edema treatment is necessary when acute encephalitis is suspected.
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