期刊
PEDIATRIC BLOOD & CANCER
卷 68, 期 1, 页码 -出版社
WILEY
DOI: 10.1002/pbc.28719
关键词
ALL; clinical trials; minimal residual disease; molecular diagnosis and therapy; pediatric oncology; T-ALL
资金
- National Institutes of Health [5P01CA068484]
- National Cancer Institute [1R01CA193651, K08CA222684]
- Enzon Pharmaceuticals
The study found that pediatric T-ALL patients have a high 5-year event-free survival and overall survival rates. The ETP phenotype may be associated with failure to achieve complete remission, but does not affect overall survival. Low end-induction MRD levels are associated with superior disease-free survival, while pathogenic mutations of the PI3K pathway may be associated with lower 5-year disease-free and overall survival rates in patients.
Background/objectives While outcomes for pediatric T-cell acute lymphoblastic leukemia (T-ALL) are favorable, there are few widely accepted prognostic factors, limiting the ability to risk stratify therapy. Design/methods Dana-Farber Cancer Institute (DFCI) Protocols 05-001 and 11-001 enrolled pediatric patients with newly diagnosed B- or T-ALL from 2005 to 2011 and from 2012 to 2015, respectively. Protocol therapy was nearly identical for patients with T-ALL (N = 123), who were all initially assigned to the high-risk arm. End-induction minimal residual disease (MRD) was assessed by reverse transcription polymerase chain reaction (RT-PCR) or next-generation sequencing (NGS), but was not used to modify postinduction therapy. Early T-cell precursor (ETP) status was determined by flow cytometry. Cases with sufficient diagnostic DNA were retrospectively evaluated by targeted NGS of known genetic drivers of T-ALL, including Notch, PI3K, and Ras pathway genes. Results The 5-year event-free survival (EFS) and overall survival (OS) for patients with T-ALL was 81% (95% CI, 73-87%) and 90% (95% CI, 83-94%), respectively. ETP phenotype was associated with failure to achieve complete remission, but not with inferior OS. Low end-induction MRD (<10(-4)) was associated with superior disease-free survival (DFS). Pathogenic mutations of the PI3K pathway were mutually exclusive of ETP phenotype and were associated with inferior 5-year DFS and OS. Conclusions Together, our findings demonstrate that ETP phenotype, end-induction MRD, and PI3K pathway mutation status are prognostically relevant in pediatric T-ALL and should be considered for risk classification in future trials. DFCI Protocols 05-001 and 11-001 are registered at as NCT00165087 and NCT01574274, respectively.
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