期刊
PATHOLOGY INTERNATIONAL
卷 71, 期 1, 页码 96-101出版社
WILEY
DOI: 10.1111/pin.13038
关键词
B cell lymphoma; composite lymphoma; p53; sclerosing cholangitis
类别
The case report describes a 70-year-old man with mantle cell lymphoma (MCL) who relapsed as a combination of MCL and classic Hodgkin lymphoma (cHL) 9 years after autologous peripheral blood stem cell transplant. The two components were phenotypically distinct but genetically related, indicating a possible transformation of MCL to HRS-like cells with EBV infection. The patient died of disease progression with elevated hepatobiliary enzymes.
The case of 70-year-old man with mantle cell lymphoma (MCL) carrying t(11;14) translocation that relapsed as nodal lymphoma combining MCL and classic Hodgkin lymphoma (cHL) 9 years after autologous peripheral blood stem cell transplant (auto-PBSCT) is reported. Lymph nodes contained two separate areas of MCL and cHL-like components. Hodgkin and Reed-Sternberg (HRS)-like cells were accompanied by a prominent histiocyte background. HRS-like cells were CD5(-), CD15(+), CD20(-), CD30(+), PAX5(+), Bob.1(-), Oct2(-)and EBER+. The MCL component expressed cyclin D1 and SOX11, whereas cyclin D1 and SOX11 expressions were reduced and lost, respectively, in HRS-like cells. Polymerase chain reaction results showed a single clonal rearrangement of theIGHgene in MCL and cHL-like components.CCND1break apart fluorescencein situhybridization showed split signals in both MCL and HRS-like cells, suggesting that MCL and cHL-like components were clonally related. Acquisition of p53 expression and Epstein-Barr virus (EBV)-positivity was seen in HRS-like cells. The patient died of disease progression with elevated hepatobiliary enzymes. The autopsy showed both MCL and cHL-like components around the bile ducts, splenic white pulp and bone marrow. The two components were phenotypically distinct, but genetically related, suggesting that transformation of MCL to HRS-like cells during the course of MCL in association with EBV infection.
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