期刊
PARASITE IMMUNOLOGY
卷 43, 期 2, 页码 -出版社
WILEY
DOI: 10.1111/pim.12798
关键词
excretory secretory antigens; immunopathology; hookworm therapy; hookworms; microbiota; vaccination
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
Hookworm infection is a prevalent human soil-transmitted helminth infection with lack of accurate surveillance mechanisms hindering control strategies. Current research sheds light on immunopathology, immunoregulation, and drug therapies for hookworm infection, offering potential for vaccine development and treatments in the future.
Hookworm infection is considered the most prevalent human soil-transmitted helminth infection affecting approximately 500 million people and accounting for 3.2 million disability-adjusted life years lost annually. As with many other neglected tropical diseases, no international surveillance mechanisms that show accurate data on the prevalence of hookworm infection are in place, thus hindering strategies to control parasite transmission. In this review, we unravel the current knowledge in immunopathology and immunoregulation of hookworm infection and present discoveries in drug therapies based on the capability of hookworms to regulate inflammation to treat allergic, inflammatory and metabolic diseases. Additionally, we highlight potential vaccine development and treatments and propose avenues for further inquiry.
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