Clinical outcomes of His-Purkinje conduction system pacing

His-Purkinje conduction system pacing (HPCSP) in the form of His bundle pacing (HBP) and left bundle branch pacing (LBBP) allows normal left ventricular activation, thereby preventing the adverse consequences of right ventricular pacing. HBP has been established for several years with centers from China, Europe, and North America reporting their experience. There is international guidance as to how to implant such systems with the differing patterns of His bundle capture clearly described. LBBP is a more recent innovation with potential advantages including improved pacing parameters. HPCSP has been extensively studied in a variety of indications including cardiac resynchronization therapy, atrioventricular node ablation, and bradycardia pacing. This review will focus on the clinical outcomes of HPCSP including mortality and morbidity of heart failure hospitalization and symptoms.

Automated summary

His-Purkinje conduction system pacing (HPCSP) with His bundle pacing (HBP) and left bundle branch pacing (LBBP) allows for normal left ventricular activation and has potential advantages, with international guidance and varying patterns of His bundle capture described. HBP has been established for several years, while LBBP is a more recent innovation. This review focuses on the clinical outcomes of HPCSP, including mortality, morbidity, and symptoms of heart failure.