期刊
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
卷 2020, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2020/5472096
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资金
- NSFC Major Research Programme from the National Natural Science Foundation of China [91739103]
- Young Scientist Fund from the National Natural Science Foundation of China [81922078]
- Early Career Scheme from the Hong Kong Research Grant Council [24122318]
- General Research Fund from the Hong Kong Research Grant Council [14109519]
- Health and Medical Research Fund from the Hong Kong Food and Health Bureau [05162906]
- School of Biomedical Sciences, Chinese University of Hong Kong
Salvia miltiorrhiza (Danshen), as an important traditional Chinese medicinal plant, has been used in China for the treatment of cardiovascular diseases for hundreds of years. Salvianolic acids (salvianolic acid A and salvianolic acid B) as the most abundant water-soluble component extracted from Salvia miltiorrhiza have attracted more and more attention from cardiovascular scientists due to its comprehensive cardiovascular actions.In vivoandin vitrostudies have rendered salvianolic acid an excellent drug candidate for the treatment and prevention of cardiovascular diseases. In this review, we surveyed the protective effects of salvianolic acid A and salvianolic acid B against cardiovascular diseases and the pharmacological basis, providing a strong scientific rationale for elucidating the important role of Salvia miltiorrhiza in cardiovascular therapy. More importantly, we also hope to provide new inspiration and perspectives on the development and innovation of small-molecule cardiovascular drugs based on salvianolic acid.
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