Polymer-Supported Chiral Cis-Disubstituted Pyrrolidine Catalysts and Their Application to Batch and Continuous-Flow Systems

Polymer-supported cis-pyrrolidine catalysts were developed that allowed for high enantioselectivity and diastereoselectivity compared with those obtained from common trans-pyrrolidine catalysts. Not only configurational but also polymeric effects contribute to the high diastereoselectivity and enantioselectivity. Polymer catalysts were also successfully applied in a continuous-flow process. Acceleration of the reaction rate, an increase in diastereoselectivity, and an improvement in durability were observed in continuous-flow operation compared with the batch system.