期刊
ORGANIC LETTERS
卷 22, 期 21, 页码 8188-8192出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02503
关键词
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资金
- National Natural Science Foundation of China [21532009, 21772198, 21871268]
- Natural Science Foundation of Guangdong Province of China [2020A1515011428]
- Guangzhou Regenerative Medicine and Health-Guangdong Laboratory of China [2018GRZ110105017]
- BAGUI Scholar Program of Guangxi Province of China
A palladium-catalyzed domino process for the quick assembly of tricyclic-fused heterocycles starting from aryl iodides and functionalized isocyanides containing a disubstituted terminal alkene has been developed. The process is triggered by intermolecular isocyanide insertion, followed by Heck-type carbopalladation of the intramolecular alkene moiety and subsequent C(sp(2))-H activation. Moreover, an asymmetric version of this reaction could also be realized in good yield with moderate enantioselectivity after preliminary exploration of chiral ligands.
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