期刊
ORGANIC LETTERS
卷 22, 期 19, 页码 7419-7423出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02353
关键词
-
资金
- National Natural Science Foundation of China [21871234]
- Zhejiang Provincial NSFC for Distinguished Young Scholars [LR15H300001]
Here, we describe a highly selective Pd-catalyzed C(sp(3))-H biarylation of 2-methylbenzaldehydes using cyclic diaryliodonium salts as arylation reagents. The key strategy is the employment of tert-leucine as a bidentate transient directing group for the proximity-driven metalation to achieve reactivity and selectivity in C-H activation. Various functionalized biaryls bearing both aldehyde and iodine functional groups were prepared successfully, which could be further transformed into a wide range of compounds with potential applications in pharmaceutical chemistry and materials science.
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