期刊
ORGANIC LETTERS
卷 22, 期 19, 页码 7522-7525出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02709
关键词
-
资金
- National Natural Science Foundation of China [81773604]
- Liaoning Natural Science Foundation [20170540856]
Two nonbiaryl axially chiral beta-carboline-quinazoline dimers, pegaharmols A (1) and B (2), were isolated from the roots of Peganum harmala. Their planar structures were elucidated by the spectroscopic methods of high-resolution mass spectrometry and 1D and 2D nuclear magnetic resonance (NMR). The stereochemistry was established by a comparison between the experimental data of NMR and electronic circular dichroism and the computed data by quantum mechanical calculations. It is discovered for the first time that the beta-carboline at the C-8 position is bonded to the vasicine at the C-9 position. 1 exhibited moderate cytotoxic activity against HL-60 and A549 cell lines.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据