期刊
ORGANIC LETTERS
卷 22, 期 18, 页码 7073-7077出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02262
关键词
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资金
- National Natural Science Foundation of China [21472077, 21772071]
- Fundamental Research Funds for the Central Universities [lzujbky-2018-134]
- Department of Education of Guangdong Province [2017KTSCX185, 2017KSYS010, 2016KCXTD005, 2019KZDXM035]
The development of methods toward the construction of quaternary carbon centers has been a hot topic in recent years. In this work, an Au(I)-catalyzed intramolecular cyclization/semipinacol rearrangement of allene-containing allylic silyl ether was developed to provide a direct strategy for the construction of multisubstituted cyclohexene-type compounds with a quaternary carbon center in moderate to good yields. In particular, this method provides an alternative synthetic strategy for the construction of a multisubstituted spirocyclo[4.5]decane skeleton and may be applied to the synthesis of related bioactive molecules and their derivatives, thus facilitating the corresponding functional studies.
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