期刊
ORGANIC LETTERS
卷 22, 期 20, 页码 8106-8110出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03061
关键词
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资金
- University of Delaware (UD)
- National Institute of General Medical Sciences [R01 GM102358]
- National Institutes of Health (NIH) funding (NSF) [CHE0421224, CHE0840401, CHE1229234]
- National Institutes of Health (NIH) funding (NIH) [S10 OD016267, S10 RR026962, P20 GM104316, P30 GM110758]
Using a commercially available, inexpensive, and abundant copper catalyst system, an efficient alpha-functionalization of nitroalkanes with propargyl bromides is now established. This mild and robust method is highly functional group tolerant and provides straightforward access to complex secondary and tertiary homopropargylic nitroalkanes. Moreover, the utility of these alpha-propargylated nitroalkanes is demonstrated through downstream functionalization to biologically relevant, five-membered Nheterocycles such as pyrroles and 2-pyrrolines.
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