4.8 Article

Copper-Catalyzed Propargylation of Nitroalkanes

期刊

ORGANIC LETTERS
卷 22, 期 20, 页码 8106-8110

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03061

关键词

-

资金

  1. University of Delaware (UD)
  2. National Institute of General Medical Sciences [R01 GM102358]
  3. National Institutes of Health (NIH) funding (NSF) [CHE0421224, CHE0840401, CHE1229234]
  4. National Institutes of Health (NIH) funding (NIH) [S10 OD016267, S10 RR026962, P20 GM104316, P30 GM110758]

向作者/读者索取更多资源

Using a commercially available, inexpensive, and abundant copper catalyst system, an efficient alpha-functionalization of nitroalkanes with propargyl bromides is now established. This mild and robust method is highly functional group tolerant and provides straightforward access to complex secondary and tertiary homopropargylic nitroalkanes. Moreover, the utility of these alpha-propargylated nitroalkanes is demonstrated through downstream functionalization to biologically relevant, five-membered Nheterocycles such as pyrroles and 2-pyrrolines.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据