期刊
ORGANIC LETTERS
卷 22, 期 20, 页码 8132-8138出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03110
关键词
-
资金
- Toray Science Foundation
- Naito Foundation
- Futaba Electronics Memorial Foundation
- Takeda Science Foundation
- Chugai Award in Synthetic Organic Chemistry, Japan
- JSPS KAKENHI [JP18H02550, 18K05098, 20J11421]
- Grants-in-Aid for Scientific Research [20J11421, 18K05098] Funding Source: KAKEN
A chemoselective dearomatization of the less reactive benzenoid unit in beta-naphthol was developed. Spirocyclization with a reductant constructs a pivotal structure for drug candidates. One-pot oxidative conversion enabled the tandem dearomatization of beta-naphthol, producing conjugated tetraenone variants. The potential utility of the product as an F-selective anion sensor was also demonstrated. Theoretical studies revealed the intermediacy of silver-carbenoid species leading to chemoselective spirocyclization over arene cyclopropanation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据