期刊
ORGANIC LETTERS
卷 22, 期 21, 页码 8528-8532出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03130
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资金
- National Natural Science Foundation of China [21971080, 21971079, 21772051]
- Fundamental Research Funds for the Central Universities [CCNU15ZX002, CCNU18QN011]
- Educational Commission of Hubei Province [D20192503]
- 111 Project [B17019]
A novel and efficient multicomponent cyclization of methyl ketones, cyanamides, and arylamines for the synthesizing 2,4-diamino-1,3,5-triazines via consecutive formation of four C-N bonds is reported. This multicomponent reaction is characterized by the employment of two molecules of cyanamide for double C(sp(3))-H amination of methyl ketones, avoiding complicated prepreparation of substrates and expanding the substrate scope. Furthermore, this multicomponent cyclization strategy provides a new approach for generating diverse 2,4-diamino-1,3,5-triazines with a broad substrate scope under mild conditions.
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